H2N2V1, Main, Exploration, bibRecord, 002544

Influenza virus-specific human cytotoxic T cell clones: Heterogeneity in antigenic specificity and restriction by class II MHC products

Identifieur interne : 002544 ( Main/Exploration ); précédent : 002543; suivant : 002545

Influenza virus-specific human cytotoxic T cell clones: Heterogeneity in antigenic specificity and restriction by class II MHC products

Auteurs : David R. Kaplan [États-Unis] ; Rogers Griffith [États-Unis] ; Vivian L. Braciale [États-Unis] ; Thomas J. Braciale [États-Unis]

Source :

Cellular Immunology [ 0008-8749 ] ; 1984.

RBID : ISTEX:D337128369BA05FEF5160E69B4DB23C7E16ECC6C

Descripteurs français

English descriptors

KwdEn :
- Antigens, Viral (immunology), Clone Cells (immunology), Cross Reactions, Humans, Influenza A virus (immunology), Interleukin-2 (immunology), Karyotyping, Lymphocyte Activation, Major Histocompatibility Complex, Phenotype, T-Lymphocytes, Cytotoxic (immunology), T-Lymphocytes, Helper-Inducer (immunology).
MESH :
- chemical , immunology : Antigens, Viral, Interleukin-2.
- immunology : Clone Cells, Influenza A virus, T-Lymphocytes, Cytotoxic, T-Lymphocytes, Helper-Inducer.
Teeft :
- Allogeneic, Antigenic, Antigenic recognition, Antigenic specificity, Assay, Autologous, Autonomous proliferation, Braciale, Cell clones, Cell line, Cell lines, Clone, Complete medium, Cross Reactions, Cytotoxic, Cytotoxic function, Cytotoxicity, Effector, Exogenous, Exogenous lymphokine, Factor production, Human cytotoxic, Humans, Immunol, Incorporation, Influenza, Influenza infection, Influenza strains, Influenza virus, Kaplan, Karyotyping, Linbro, Lymphoblastoid, Lymphoblastoid cells, Lymphoblastoid stimulators, Lymphocyte, Lymphocyte Activation, Lymphokine, Major Histocompatibility Complex, Monoclonal, Monoclonal antibodies, Monomorphic determinants, Murine, Open bars, Pbmn, Phenotype, Positive wells, Proliferation, Quadruplicate wells, Restriction analysis, Specific antigenic stimulation, Standard deviations, Stimulator, Stimulator cells, Stimulators, Supematant, Supematants, Surface marker, Syngeneic, Syngeneic pbmn, Target cell groups, Target cells, Tcgf, Thymidine, Thymidine incorporation, Tissue culture plate, Total counts, Tritiated, Tritiated thymidine incorporation, Uninfected, Uninfected lymphoblastoid cells, Viral, Viral recognition, Viral specificity, Washington university.

Abstract

Abstract: Human cytotoxic T lymphocytes specific for A/JAP/57 (H2N2) influenza virus were cloned from in vitro stimulations of peripheral blood lymphocytes. Analysis of the viral specificity in cytotoxic function revealed one clone that killed all type A influenza-infected targets, another clone that was specific for the hemagglutinin subtype of the immunizing influenza virus, and the third clone that demonstrated cytotoxicity restricted to the hemagglutinin of A/JAP/57 and A/JAP/62 (H2N2) and not other type A influenza strains with the H2N2 subtypes. The phenotype of these three clones was Leu 2−, Leu 3+, Leu 4+; MHC restriction of their cytotoxic function was mapped to HLA-DR by a panel of target cells as well as by inhibition of cytotoxicity with monoclonal antibodies. Proliferation of these clones, examined in a tritiated thymidine incorporation assay, was found to be driven by antigen in the absence of exogenous lymphokines. For all three clones antigen-dependent production and secretion of lymphokines with IL-2 activity was demonstrated. The antigen specificity of proliferation and factor production was shown to be identical to the pattern that each clone revealed in its cytotoxic function.

Url:

https://api.istex.fr/ark:/67375/6H6-D9HRRNG2-P/fulltext.pdf

DOI: 10.1016/0008-8749(84)90064-9

Affiliations:

Le document en format XML

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<term>Clone Cells (immunology)</term>
<term>Cross Reactions</term>
<term>Humans</term>
<term>Influenza A virus (immunology)</term>
<term>Interleukin-2 (immunology)</term>
<term>Karyotyping</term>
<term>Lymphocyte Activation</term>
<term>Major Histocompatibility Complex</term>
<term>Phenotype</term>
<term>T-Lymphocytes, Cytotoxic (immunology)</term>
<term>T-Lymphocytes, Helper-Inducer (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Antigènes viraux (immunologie)</term>
<term>Caryotypage</term>
<term>Clones cellulaires (immunologie)</term>
<term>Complexe majeur d'histocompatibilité</term>
<term>Humains</term>
<term>Interleukine-2 (immunologie)</term>
<term>Lymphocytes T auxiliaires (immunologie)</term>
<term>Lymphocytes T cytotoxiques (immunologie)</term>
<term>Phénotype</term>
<term>Réactions croisées</term>
<term>Virus de la grippe A (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term>
<term>Interleukin-2</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term>
<term>Clones cellulaires</term>
<term>Interleukine-2</term>
<term>Lymphocytes T auxiliaires</term>
<term>Lymphocytes T cytotoxiques</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Clone Cells</term>
<term>Influenza A virus</term>
<term>T-Lymphocytes, Cytotoxic</term>
<term>T-Lymphocytes, Helper-Inducer</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Allogeneic</term>
<term>Antigenic</term>
<term>Antigenic recognition</term>
<term>Antigenic specificity</term>
<term>Assay</term>
<term>Autologous</term>
<term>Autonomous proliferation</term>
<term>Braciale</term>
<term>Cell clones</term>
<term>Cell line</term>
<term>Cell lines</term>
<term>Clone</term>
<term>Complete medium</term>
<term>Cross Reactions</term>
<term>Cytotoxic</term>
<term>Cytotoxic function</term>
<term>Cytotoxicity</term>
<term>Effector</term>
<term>Exogenous</term>
<term>Exogenous lymphokine</term>
<term>Factor production</term>
<term>Human cytotoxic</term>
<term>Humans</term>
<term>Immunol</term>
<term>Incorporation</term>
<term>Influenza</term>
<term>Influenza infection</term>
<term>Influenza strains</term>
<term>Influenza virus</term>
<term>Kaplan</term>
<term>Karyotyping</term>
<term>Linbro</term>
<term>Lymphoblastoid</term>
<term>Lymphoblastoid cells</term>
<term>Lymphoblastoid stimulators</term>
<term>Lymphocyte</term>
<term>Lymphocyte Activation</term>
<term>Lymphokine</term>
<term>Major Histocompatibility Complex</term>
<term>Monoclonal</term>
<term>Monoclonal antibodies</term>
<term>Monomorphic determinants</term>
<term>Murine</term>
<term>Open bars</term>
<term>Pbmn</term>
<term>Phenotype</term>
<term>Positive wells</term>
<term>Proliferation</term>
<term>Quadruplicate wells</term>
<term>Restriction analysis</term>
<term>Specific antigenic stimulation</term>
<term>Standard deviations</term>
<term>Stimulator</term>
<term>Stimulator cells</term>
<term>Stimulators</term>
<term>Supematant</term>
<term>Supematants</term>
<term>Surface marker</term>
<term>Syngeneic</term>
<term>Syngeneic pbmn</term>
<term>Target cell groups</term>
<term>Target cells</term>
<term>Tcgf</term>
<term>Thymidine</term>
<term>Thymidine incorporation</term>
<term>Tissue culture plate</term>
<term>Total counts</term>
<term>Tritiated</term>
<term>Tritiated thymidine incorporation</term>
<term>Uninfected</term>
<term>Uninfected lymphoblastoid cells</term>
<term>Viral</term>
<term>Viral recognition</term>
<term>Viral specificity</term>
<term>Washington university</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Caryotypage</term>
<term>Complexe majeur d'histocompatibilité</term>
<term>Humains</term>
<term>Phénotype</term>
<term>Réactions croisées</term>
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<front><div type="abstract" xml:lang="en">Abstract: Human cytotoxic T lymphocytes specific for A/JAP/57 (H2N2) influenza virus were cloned from in vitro stimulations of peripheral blood lymphocytes. Analysis of the viral specificity in cytotoxic function revealed one clone that killed all type A influenza-infected targets, another clone that was specific for the hemagglutinin subtype of the immunizing influenza virus, and the third clone that demonstrated cytotoxicity restricted to the hemagglutinin of A/JAP/57 and A/JAP/62 (H2N2) and not other type A influenza strains with the H2N2 subtypes. The phenotype of these three clones was Leu 2−, Leu 3+, Leu 4+; MHC restriction of their cytotoxic function was mapped to HLA-DR by a panel of target cells as well as by inhibition of cytotoxicity with monoclonal antibodies. Proliferation of these clones, examined in a tritiated thymidine incorporation assay, was found to be driven by antigen in the absence of exogenous lymphokines. For all three clones antigen-dependent production and secretion of lymphokines with IL-2 activity was demonstrated. The antigen specificity of proliferation and factor production was shown to be identical to the pattern that each clone revealed in its cytotoxic function.</div>
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Influenza virus-specific human cytotoxic T cell clones: Heterogeneity in antigenic specificity and restriction by class II MHC products

Influenza virus-specific human cytotoxic T cell clones: Heterogeneity in antigenic specificity and restriction by class II MHC products

Source :

Descripteurs français

English descriptors

Abstract

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